徐志超教授，博士生导师
E-mail: zcxu@nefu.edu.cn
beat365官方网站（新逸夫教学楼507）
工作经历
2021-05至现在，beat365官方网站，beat365官方网站，教授
2016-08至2021-05，中国医学科学院药用植物研究所，助理研究员，副研究员
2019-09至2020-09，VIB - UGent Center for Plant Systems Biology，访问学者
研究领域
本草基因组学；天然产物生物合成及调控；合成生物学；分子辅助育种；分子鉴定
科研项目（主持）
[1]濒危药材关黄柏活性成分小檗碱的生物合成机制研究，2023-2026，国家自然科学基金面上项目
[2]西红花苷生源途径解析及合成生物学研究，2020-2023，国家自然科学基金面上项目
[3]中药多组学方法创新及新品种选育研究，2019-2021，国家重点研发计划-课题负责人
[4]丹参酮生物合成关键酶短链脱氢酶编码基因的克隆和功能鉴定，2018-2020，国家自然科学基金青年科学基金
[5]中药原料及相应中成药的全程质量追溯关键技术，2019-2020，重大新药创制-任务负责人
代表性论文（第一及通讯，IF2022）
1. Wei Sun#, Qinggang Yin#, Huihua Wan#, Ranran Gao#, Chao Xiong, Chong Xie, Xiangxiao Meng, Yaolei Mi, Xiaotong Wang, Caixia Wang, Weiqiang Chen, Ziyan Xie, Zheyong Xue, Hui Yao, Peng Sun, Xuehua Xie, Zhigang Hu, David R. Nelson,Zhichao Xu*, Xinxiao Sun*, Shilin Chen*. Characterization of the horse chestnut genome reveals the evolution of aescin and aesculin biosynthesis.Nature Communications, 2023, 14: 6470 (IF=16.6)
2. Jiadong Hu#, Shi Qiu#*, Feiyan Wang#, Qing Li#, Chun-Lei Xiang, Peng Di, Ziding Wu, Rui Jiang, Jinxing Li, Zhen Zeng, Jing Wang, Xingxing Wang, Yuchen Zhang, Shiyuan Fang, Yuqi Qiao, Jie Ding, Yun Jiang,Zhichao Xu*, Junfeng Chen*, Wansheng Chen*.Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genusSalvia.Nature Communications, 2023, 14: 4696 (IF=16.6)
3. Ziyan Xie#, Yaolei Mi#, Lingzhe Kong, Maolun Gao, Shanshan Chen, Weiqiang Chen, Xiangxiao Meng, Wei Sun*, Shilin Chen*,Zhichao Xu*.Cannabis sativa: origin and history, glandular trichome development, and cannabinoid biosynthesis,Horticulture Research, 2023, uhad150. (IF=8.7)
4. Wei Sun#,Zhichao Xu#,Chi Song, Shilin Chen*. Herbgenomics: Decipher molecular genetics of medicinal plants,Innovation, 2022, 3(6): 100322. (IF=32.1)
5.Zhichao Xu#, Zhen Li#, Fengming Ren#, Ranran Gao#, Zhe Wang, Jinlan Zhang, Tao Zhao, Xiao Ma, Xiangdong Pu, Tianyi Xin, Stephane Rombauts, Wei Sun, Yves Van de Peer*, Shilin Chen*, Jingyuan Song*. The genome ofCorydalisreveals the evolution of benzylisoquinoline alkaloid biosynthesis in Ranunculales.Plant Journal, 2022, 111(1):217-230 (IF=7.2)
6. Ranran Gao, Qian Lou, Lijun Hao, Guihong Qi, Ya Tian, Xiangdong Pu, Chunnian He, Yu Wang, Wenjie Xu,Zhichao Xu*, Jingyuan Song*. Comparative genomics reveal the convergent evolution of CYP82D and CYP706X members related to flavone biosynthesis in Lamiaceae and Asteraceae.Plant Journal, 2022, 109(5):1305-1318*Corresponding author(IF=7.2)
7. Xinyi Yang#, Sihao Zheng#, Xiaotong Wang, Jing Wang, Syed Basit Ali Shah, Yu Wang*, Ranran Gao*,Zhichao Xu*.Advances in pharmacology, biosynthesis, and metabolic engineering ofScutellaria-specialized metabolites,Critical Reviews in Biotechnology, 2022, https://doi.org/10.1080/07388551.2022.2149386. (IF=9.0)
8. Baoshi Wang*, Guangyao Li, Linbo Li, Mingxia Zhang, Tianyou Yang,Zhichao Xu*,Tengfei Qin*. Novel processing strategies to enhance the bioaccessibility and bioavailability of functional components in wheat bran.Critical Reviews in Food Science and Nutrition, 2022, https://doi.org/10.1080/10408398.2022.2129582. (IF=10.2)
9. Xiangdong Pu, Zhen Li, Ya Tian, Ranran Gao, Lijun Hao, Yating Hu, Chunnian He, Wei Sun, Meimei Xu, Reuben J. Peters, Yves Van de Peer,Zhichao Xu*,Jingyuan Song*. The honeysuckle genome provides insight into the molecular mechanism of carotenoid metabolism underlying dynamic flower coloration.New Phytologist, 2020,227(3):930-943.*Corresponding author(IF=9.4)
10.Zhichao Xu#, Xiangdong Pu#, Ranran Gao, Olivia Costantina Demurtas, Steven J. Fleck, Michaela Richter, Chunnian He, Aijia Ji, Wei Sun, Jianqiang Kong, Kaizhi Hu, Fengming Ren, Jiejie Song, Zhe Wang, Ting Gao, Chao Xiong, Haoying Yu, Tianyi Xin, Victor A. Albert, Giovanni Giuliano*, Shilin Chen*, Jingyuan Song*. Tandem gene duplications drive divergent evolution of caffeine and crocin biosynthetic pathways in plants.BMC Biology, 2020, 18: 63. (IF=5.4)HIGHLIGHT
11.Zhichao Xu#, Ranran Gao#, Xiangdong Pu, Rong Xu, Jiyong Wang, Sihao Zheng, Yan Zeng, Jun Chen, Chunnian He, Jingyuan Song*. Comparative Genome Analysis ofScutellaria baicalensisandScutellaria barbataReveals the Evolution of Active Flavonoid Biosynthesis.Genomics Proteomics and Bioinformatics, 2020, 18: 230-240. (IF= 9.5)
12. Xiangdong Pu, Chunnian He, Yan Yang, Wei Wang, Kaizhi Hu,Zhichao Xu*,Jingyuan Song*.In VivoProduction of Five Crocins in the EngineeredEscherichia coli.ACS Synthetic Biology, 2020, 9, 5, 1160-1168. (IF=4.7)*Corresponding authorCover story
13. Shasha Wu#, Wei Sun#,Zhichao Xu#, Junwen Zhai#, Xiaoping Li, Chengru Li, Diyang Zhang, Xiaoqian Wu, Liming Shen, Junhao Chen, Hui Ren, Xiaoyu Dai, Zhongwu Dai, Yamei Zhao, Lei Chen, Mengxia Cao, Xinyu Xie, Xuedie Liu, Donghui Peng, Jianwen Dong, Yu-Yun Hsiao, Shi-lin Chen*, Wen-Chieh Tsai*, Siren Lan*, Zhongjian Liu*. The genome sequence of star fruitAverrhoa carambola.Horticulture Research, 2020, 7: 95. (IF=8.7)#Co-one author
14. Tianyi Xin, Yu Zhang, Xiangdong Pu, Ranran Gao,Zhichao Xu*and Jingyuan Song*. Trends in Herbgenomics.SCIENCE CHINA Life Sciences, 2019, 62(3): 288-308. (IF=9.1)*Corresponding author
15.Zhichao Xu, Tianyi Xin, Dorothea Bartels, Ying Li, Wei Gu, Hui Yao, Sai Liu, Haoying Yu, Xiangdong Pu, Jianguo Zhou, Jiang Xu, Caicai Xi, Hetian Lei, Jingyuan Song*and Shilin Chen*.Genome analysis of the ancient tracheophyteSelaginella tamariscinareveals evolutionary features relevant to the acquisition of desiccation tolerance.Molecular Plant, 2018, 11: 983-994. (IF=27.5)ESI Highly Cited Paper
16.Tianyi Xin, Chang Su, Yulin Lin, Shuhong Wang,Zhichao Xu*, Jingyuan Song*. Precise species detection of traditional Chinese patent medicine by shotgun metagenomic sequencing.Phytomedicine,2018, 47: 40-47. (IF=7.9)*Corresponding author
17.Zhichao Xuand Jingyuan Song*.The 2-oxoglutarate-dependent dioxygenase superfamily participates in tanshinone production ofSalvia miltiorrhiza.Journal of Experimental Botany, 2017, 68 (9): 2299-2308. (IF= 6.9)
18.Zhichao Xu#, Reuben J. Peters#, Jason Weirather, Hongmei Luo, Baosheng Liao, Xin Zhang, Yingjie Zhu, Aijia Ji, Bing Zhang, Songnian Hu, Kin Fai Au, Jingyuan Song*, Shilin Chen*.Full-length transcriptome sequences and splice variants obtained by a combination of sequencing platforms applied to different root tissues ofSalvia miltiorrhizaand tanshinone biosynthesis.Plant Journal, 2015, 82:951-961. (IF=7.2)ESI Highly Cited Paper;TOP5 most cited articles over 2016-2017 (Plant Journal)
出版著作
[1]《药用植物分子遗传学》科学出版社2022
[2]《本草基因组学-中药组学的发展与未来》科学出版社2016
[3]《本草基因组学》全国高等医药院校规划教材科学出版社2018
[4]《药用植物品质生物学》科学出版社2019
[5] “The Genome ofSalvia miltiorrhiza” of《TheSalvia miltiorrhizaGenome》Springer 2019
奖励
[1]中草药国际通用DNA条形码鉴定体系，世界中医药学会联合会，中医药国际贡献奖科技进步奖，一等奖，2018（12/14）
[2]黑龙江省高等教育和职业教育教学成果奖一等奖（15/17）
授权专利
[1]一种基于宏基因组的中成药质量控制方法，2022，美国专利：US 11,398,294 B2（3/4）
[2]参与西红花苷合成的糖基转移酶GjUGT94E13和GjUGT74F8的筛选鉴定及应用，2022，中国专利：ZL201810867889.1（3/4）
[3]一种参与挥发性成分形成的类胡萝卜素裂解双加氧酶编码基因的筛选鉴定及应用，2022，中国专利：ZL202010017042.1（3/4）
[4]一种参与金银花花色变化的类萝卜素裂解双加氧酶编码基因的筛选鉴定及应用，2022，中国专利：ZL201910639359.6 (3/4)
