金丽华教授,博士生导师,遗传学科学科带头人
联系电话:15046109867
E-mail:lhjin@nefu.edu.cn, lhjin2000@hotmail.com
地址:黑龙江省哈尔滨市香坊区和兴路26号
beat365官方网站(新逸夫教学楼) 254房间
学习经历
2000.03-2003.02 韩国翰林大学老化生命科学理学博士
1998.03-2000.02 韩国江原大学应用生物与技术理学硕士
1989.09-1993.06 延边大学化学系学士
工作经历
2009.07月-至今beat365官方网站遗传学科教授博士生导师
2005.08-2009.06 韩国延世大学基因调解中心研究教授
2003.03-2005.07 韩国延世大学基因调解中心博士后
专业特长:
遗传学、分子生物学、细胞生物学、生物化学
研究方向:
细胞与分子免疫、遗传与发育、疾病发生的分子机制、中药及次生代谢产物的药理作用
研究领域:
1、细胞与分子免疫:从分子水平揭示重要基因在细胞免疫、体液免疫、肠道免疫中的功能及在体内的调控机理。
2、遗传与发育:揭示功能基因对个体生长发育、衰老、疾病发生、肿瘤形成等的影响及其分子机制。
3、中药药理:中药及次生代谢产物在天然免疫、肠道免疫、脂肪代谢、抗氧化、抗衰老、抗肿瘤等的功能及作用。
承担教学:
遗传学、遗传与免疫、分子免疫、最新遗传学进展
承担的科研项目:
2022.01-2025.12 国家自然科学基金主持人
果蝇Rab1蛋白在造血干细胞稳态维持中的作用机制
2018.01-2021.12 国家自然科学基金主持人
Rab5蛋白调控果蝇造血作用的分子机制
2016.03-2020.02 中央高校基本科研业务费专项资金项目主持人
创新团队与重大项目培育资金
药用植物药理及生理生态适应性研究主持人
2016.07-2019.06 黑龙江省基金主持人
药用植物对果蝇肠道免疫和胰岛素代谢的调节作用
2014.01 - 2016.12 高等学校博士学科点专项科研基金主持人
2013.01 - 2016.12 国家自然科学基金主持人
2013.04 - 2016.03 中央高校基本科研业务费专项资金项目主持人
创新团队与重大项目培育资金
2012.01 - 2014.12教育部留学回国人员科研启动基金主持人
2011.01 - 2013.12 国家人事部留学人员科技活动项目择优资助经费主持人
2011.01 - 2013.12国家自然科学基金主持人
2010.10 - 2013.10 中央高校基本科研业务费专项资金项目主持人
杰出青年科研人才基金项目
2010.01 - 2010.12 国家自然科学基金,主持人
2009.08 - 2011.12 beat365官方网站高层次引进人才科研启动项目主持人
主要发表学术论文(*为通讯作者):
1. Shichao Yu†, Fangzhou Luo†, Yongyi Xu, Yan Zhang,Li Hua Jin*Drosophila Innate Immunity Involves Multiple Signaling Pathways and Coordinated Communication Between Different Tissues.Frontiers in immunology. 2022, 13:905370.医学2区, Top期刊, IF 8.78
2. Xue Lei, Ziqian Zhou, Sihong Wang,Li Hua Jin*The protective effect of safranal against intestinal tissue damage in Drosophila.Toxicology and Applied Pharmacology.2022, 439:115939.毒理学2区, IF4.16
3. Jiewei Wang, Qiang Liu, Yuan Gong,Li Hua Jin*. Anchor maintains gut homeostasis by restricting the JNK and Notch pathways in Drosophila.Journal of Insect Physiology. 2021, 134: 104309.农林科学2区, IF 2.60
4. Shichao Yu, Fangzhou Luo,Li Hua Jin*. Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in Drosophila.Elife. 2021, 10:e60870.生物学1区, Top期刊, IF 8.71
此项研究成果被新华社、中新网和央广网等媒体报道https://baijiahao.baidu.com/s?id=1694810822594054388&wfr=spider&for=pc
5. Fangzhou Luo, Shichao Yu,Li Hua Jin*. The Posterior Signaling Center Is an Important Microenvironment for Homeostasis of the Drosophila Lymph Gland.Frontiers in Cell and Developmental Biology. 2020, 8:382.生物学2区,
IF 6.08
6. Hong Zhang, Sihong Wang,Li Hua Jin*. A canthopanax senticosus polysaccharide regulates the proliferation and differentiation of Drosophila intestinal stem cells. Phytotherapy Research. 2020,34:193-200.医学2区, IF 6.39
7. Xiaochun Wang, Ziguang Liu,Li Hua Jin*. Drosophila jumu modulates apoptosis via a JNK-dependent pathway and is required for other processes in wing development.Apoptosis. 2019, 24:465-477.生物2区, IF 5.56
8. Yangguang Hao, Shichao Yu, Fangzhou Luo,Li Hua Jin*. Jumu is required for circulating hemocyte differentiation and phagocytosis in Drosophila.Cell Communication and Signaling. 2018, 5;16:95.生物2区, IF7.52
9. Xiao Chun Wang, Ziguang Liu ,Li Hua Jin*. Anchor negatively regulates BMP signalling to control Drosophila wing development.European Journal of Cell Biology. 2018, 97:308-317.生物3区, IF 6.0
10. Shichao Yu, Gaoqun Zhang,Li Hua Jin*. A high-sugar diet affects cellular and humoral immune responses in Drosophila.Experimental cell research. 2018, 15;368:215-224.医学3区, IF 4.1
11. Shichao Yu, Fangzhou Luo,Li Hua Jin*.The Drosophila lymph gland is an ideal model for studying hematopoiesis.Developmental and Comparative Immunology. 2018, 83:60-69.生物2区, Top期刊, IF 3.6
12. Qiang Liu andLi Hua Jin*. The zinc finger protein CG12744 is essential for differentiation and regeneration after infection in the adult Drosophila midgut.Experimental Cell Research. 2017, 361:225-235.医学3区, IF 4.1
13. Qiang Liu andLi Hua Jin*.Tissue-resident stem cell activity: a view from the adultDrosophilagastrointestinal tract.Cell Communication and Signaling. 2017, 18;15:33.生物2区, IF 7.52
14. Qiang Liu andLi Hua Jin*. Organ-to-Organ Communication: A Drosophila Gastrointestinal Tract Perspective.Frontiers in Cell and Developmental Biology. 2017,3;5:29.生物2区, IF 6.1
15. Xiaoyue Zhang, Qiuxia Jin,Li Hua Jin*.High sugar diet disrupts gut homeostasis though JNK and STAT pathways in Drosophila.Biochemical and Biophysical Research Communications. 2017, 487: 910-916.生物3区, IF 3.3
16.Yangguang Hao,Li Hua Jin*.Dual role for Jumu in the control of hematopoietic progenitors in the Drosophila lymph gland.eLife. 2017;6:e25094.生物1区, Top期刊, IF 8.71
17. Gaoqun Zhang, Yangguang Hao,Li Hua Jin*. Overexpression of jumu induces melanotic nodules by activating Toll signaling in Drosophila.Insect Biochemistry and Molecular Biology. 2016,77:31-38.农林科学1区, Top期刊,IF 4.4
18.Jichuan Pan,Li Hua Jin*. rgn gene is required for gut cell homeostasis after ingestion of sodium dodecyl sulfate inDrosophila.Gene.2014,549:141-148.生物3区, IF 3.9
19.Caixia Zhu, Fachun Guan, Chao Wang,Li Hua Jin*.The Protective Effects of Rhodiola crenulata Extracts onDrosophila melanogasterGut Immunity Induced by Bacteria and SDSToxicity.Phytotherapy Research. 2014,28:1861-1866.医学2区, IF 6.39
20.Li Hua Jin, Jung Kyoon Choi, Byungil Kim,Hwan Sung Cho,Jihyun Kim,Jeongsil Kim-Ha, Young-Joon Kim*. Requirement of Split ends for Epigenetic Regulation of Notch Signal-Dependent Genes during Infection-Induced Hemocyte Differentiation.Molecular and Cellular Biology, 2009, 29:1515-1525.生物3区, IF 5.0
21.Li Hua Jin, Jaewon Shim, Joon Sun Yoon, Byungil Kim, Jihyun Kim, Jeongsil Kim-Ha, Young-Joon Kim*. Identification and Functional Analysis of Antifungal Immune Response Genes in Drosophila.PLoS Pathogens, 2008, 4:e1000168.
生物1区, Top期刊, IF7.46
授权发明专利:
1.金丽华;李娜.板蓝根提取物对果蝇杀虫作用的应用.
专利号:201811463244.8
2.金丽华;于世超;柳宗琳. 藏红花在缓解果蝇肠道炎症损伤中的应用.
专利号:ZL201510623731.6
3.金丽华;于世超;王超.工布乌头在缓解果蝇肠道炎症损伤中的应用.
专利号:201510377387.7
4.金丽华;周洋.瓜蒌、红花和川穹在缓解果蝇肠道氧化应激损伤中的应用.
专利号:201410155605.8
5.金丽华;朱彩霞;关法春;兰小中.西藏大花红景天提取物在制备抗肠道炎症药物中的应用.专利号:201310594361.9
6.金丽华,张玮钰,李文佳.刺五加水提取物在缓解果蝇肠道炎症中的应用.
专利号:ZL201210299779.2
获奖:
1.中国林业青年科技奖(第十二届林业青年科技奖)(国家林业局)2013年9月
木本药用植物对免疫功能及胰岛素代谢的影响
2.黑龙江省自然科学奖三等奖(黑龙江省科技厅),beat365官方网站金丽华,郝阳光,刘强,张高群,李文佳 2020年9月