报告题目：Dynamics of Stem Cell Signaling Pathways in Meristems
报 告 人：Rüdiger Simon教授 德国杜塞尔多夫大学，遗传学研究所，Cluster of Excellence on Plant Sciences负责人
报告时间：2015年12月17日（周四）下午14：00分
报告地点：beat365官方网站新逸夫教学楼608会议室
报告人简历：
Rüdiger Simon教授，男，现任德国杜塞尔多夫大学，遗传学研究所，Cluster of Excellence on Plant Sciences负责人、Center for Advanced Imaging (CAi)中心负责人及Developmental Genetics实验室负责人。Simon实验室以拟南芥、油菜籽和短柄草为模型，主要进行植物发育方向的研究，重点致力于植物干细胞信号传导、器官分化起始以及在发育过程中时空水平上细胞命运决定机制的研究。研究成果在Nature、Science、 Cell等顶级刊物上多次发表，对植物干细胞领域的研究有重大影响。
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Simon教授的讲座摘要:
Dynamics of stem cell signaling pathways in meristems
Organogenesis in plants is based on precise cell fate determination of undifferentiated cells, which are derived from stem cells that reside in meristems. Cell fate determination depends on the position of a cell within the plant body. A number of mechanisms provide positional information to cells or cell populations: (1) plant hormones like auxin establish gradients or local concentration maxima; (2) secreted ligands and membrane associated receptors enables cell-cell signaling between adjacent cell layers; (3) transcription factors can act non-cell autonomously to integrate cellular responses, and (4) long range communication takes place by transport of signals between cells through plasmodesmata.
Our current understanding is that these mechanisms act in a concerted manner to govern plant development. I will report on our most recent results on receptor kinase signaling pathways that control the growth and maintenance of meristems. Using a toolbox of fluorescence imaging techniques in planta, we studied the dynamics of receptor assembly into larger complexes at distinct regions of the plasmamembranes upon the perception of their specific ligands. Furthermore, we found that alterations of receptor expression levels can have profound developmental consequences. Finally, I will try to link aspects of peptide-receptor and hormonal signaling pathways, and highlight important commonalities and differences between developmental and pathogen response pathways.
