华欣

发布时间:2023-02-23来源:beat365官方网站 浏览次数:


华欣,男,黑龙江人,副教授,博士生导师。2007年毕业于中国药科大学、2014年获得beat365官方网站博士研究生学位、先后在美国德克萨斯州立大学药学院及中国农业科学院哈尔滨兽医研究所进行访学交流及博士后工作。2014-2018年在中国农业科学院哈尔滨兽医研究所担任助理员研究院及副研究员,现任beat365官方网站副教授,博士研究生导师。主要研究方向为药用天然产物开发与利用,其中包括药用天然活性产物筛选、活性机制研究以及药用天然产物代谢途径解析等。主持国家自然科学基金青年基金、黑龙江省自然科学基金优秀青年项目等7项课题。在Communications Biology、Journal of Agriculture and Food Chemistry、Phytomedicine等学术期刊发表论文共20余篇,申请和授权国内外专利4项。

教育和训练经历:

2003/9 - 2007/7,中国药科大学,药学,药学院,药学专业学士

2008/9 - 2014/7,beat365官方网站,森林植物生态学教育部重点实验室,植物学博士

2012/10 - 2013/10,美国德克萨斯州立大学,药学院,联合培养博士

2014/7 - 2018/6,中国农业科学院哈尔滨兽医研究所,细菌病研究团队,博士后

工作经历:

2007/7 - 2012/7,浙江海正药业,新药研发部,研发专员

2014/7 – 2018/7,中国农业科学院哈尔滨兽医研究所,细菌病研究团队,助理研究员

2018/7-至今,beat365官方网站,beat365官方网站,副教授

专业特长:

天然活性产物筛选,药物分析,药物代谢,药理学,药用植物次生代谢产物途径解析。

研究经验和研究领域:

利用分子生物学、信息生物学、代谢组学、分析化学等手段解析天然药用植物中主要活性物质的代谢途径;筛选具有抗肿瘤、抗菌、抗病毒等活性的天然活性物质并研究其发挥活性的分子机制。

教学情况:

承担本科生课程《天然活性产物分析》和《免疫学原理与技术》

近年承担的主要课题:

1.黑龙江省自然科学基金优秀青年项目:基于木豆芪酸的多粘菌素耐药关键蛋白MCR-1抑制剂开发(YQ2020C020),2020.07-2023.07,负责人:华欣

2.黑龙江省博士后科研启动金一等资助:多粘菌素耐药蛋白MCR-1高活性抑制剂挖掘(LBH-Q19003),负责人:华欣

3.中央高校基本科研业务费专项资金项目:刺五加基因组测序及重要活性成分相关基因的挖掘(2572020BD01),2020.09-2023.08,负责人:华欣

4.国家自然科学基金青年基金项目:香鳞毛蕨素抗甲氧西林耐药金黄色葡萄球菌分子作用机制研究(31602100),2017.01-2019.12,负责人:华欣

5.黑龙江省科学基金面上项目:木豆叶抗奶牛源MRSA活性成分筛选及其抗菌机制研究(C2016063),2016.6-2019.6,负责人:华欣。

6.中国博士后科学基金: 香鳞毛蕨单体活性成分的抗MRSA分子机制研究(2016M591311),2016.6-2018.6,负责人:华欣。

第一作者及通讯作者文章:

1.Zhang Y, Wang W, Chen Z, Shi H, Zhang W, Zhang X,Hua X*: An artificial bone filling material of poly l-lactic acid/collagen/nano-hydroxyapatite microspheres: Preparation and collagen regulation on the property.International journal of biological macromolecules2023,229:35-50.

2.Wang Z, Efferth T,Hua X*, Zhang XA: Medicinal plants and their secondary metabolites in alleviating knee osteoarthritis: A systematic review.Phytomedicine2022, 105:154347.

3.Zhang H&,Hua X&, Zheng D, Wu H, Li C, Rao P, Wen M, Choi YE, Xue Z, Wang Yet al: De Novo Biosynthesis of Oleanane-Type Ginsenosides in Saccharomyces cerevisiae Using Two Types of Glycosyltransferases from Panax ginseng.J Agric Food Chem2022, 70(7):2231-2240.

4.Liang M, Ge X, Xua H, Ma K, Zhang W, Zan Y, Efferth T, Xue Z,Hua X*: Phytochemicals with activity against methicillin-resistant Staphylococcus aureus.Phytomedicine2022, 100:154073.

5.Hua X, Song W, Wang K, Yin X, Hao C, Duan B, Xu Z, Su T, Xue Z: Effective prediction of biosynthetic pathway genes involved in bioactive polyphyllins in Paris polyphylla.Commun Biol2022, 5(1):50.

6.Li J, Yan G, Duan X, Zhang K, Zhang X, Zhou Y, Wu C, Zhang X, Tan S,Hua Xet al: Research Progress and Trends in Metabolomics of Fruit Trees.Frontiers in plant science2022,13:881856.

7.Jia Y, Hao C, Yang Q, Zhang W, Li G, Liu S,Hua X*: Inhibition of Haemophilus parasuis by berberine and proteomic studies of its mechanism of action.Res Vet Sci2021, 138:62-68.

8.Tan S,Hua X*, Xue Z, Ma J: Cajanin Stilbene Acid Inhibited Vancomycin-Resistant Enterococcus by Inhibiting Phosphotransferase System.Front Pharmacol2020, 11:473.

9.Hua X, Jia Y, Yang Q, Zhang W, Dong Z, Liu S: Transcriptional Analysis of the Effects of Gambogic Acid and Neogambogic Acid on Methicillin-Resistant Staphylococcus aureus.Front Pharmacol2019, 10:986.

10.Hua X, Yang Q, Zhang W, Dong Z, Yu S, Schwarz S, Liu S: Antibacterial Activity and Mechanism of Action of Aspidinol Against Multi-Drug-Resistant Methicillin-Resistant Staphylococcus aureus.Front Pharmacol2018, 9:619.

11.Hua X, Yang Q, Dong Z, Zhang J, Zhang W, Wang Q, Tan S, Smyth HD: Magnetically triggered drug release from nanoparticles and its applications in anti-tumor treatment.Drug Deliv2017, 24(1):511-518.

12.Tan S, Dong Z, Zhang J, Efferth T, Fu Y,Hua X*: Cytochrome P450 reaction phenotyping and inhibition and induction studies of pinostrobin in human liver microsomes and hepatocytes.Biomed Chromatogr2017, 31(6).

13.Hua X, Peng X, Tan S, Li C, Wang W, Luo M, Fu Y, Zu Y, Smyth H: In vitro oxidative metabolism of cajaninstilbene Acid by human liver microsomes and hepatocytes: involvement of cytochrome p450 reaction phenotyping, inhibition, and induction studies.J Agric Food Chem2014, 62(43):10604-10614.

14.Hua X, Tan S, Bandara HM, Fu Y, Liu S, Smyth HD: Externally controlled triggered-release of drug from PLGA micro and nanoparticles.PLoS One2014, 9(12):e114271.

15.Hua X, Fu YJ, Zu YG, Zhang L, Wang W, Luo M: Determination of pinostrobin in rat plasma by LC-MS/MS: application to pharmacokinetics.J Pharm Biomed Anal2011, 56(4):841-845.

16.Hua X, Fu YJ, Zu YG, Wu N, Kong Y, Li J, Peng X, Efferth T: Plasma pharmacokinetics and tissue distribution study of cajaninstilbene acid in rats by liquid chromatography with tandem mass spectrometry.J Pharm Biomed Anal2010, 52(2):273-279.

其他文章

1.Wang X, Zhu Y,Hua X, Chen F, Wang C, Zhang Y, Liu S, Zhang W: F14:A-:B- and IncX4 Inc group cfr-positive plasmids circulating in Escherichia coli of animal origin in Northeast China.Vet Microbiol2018, 217:53-57.

2.Wang XM, Dong Z, Schwarz S, Zhu Y,Hua X, Zhang Y, Liu S, Zhang WJ: Plasmids of Diverse Inc Groups Disseminate the Fosfomycin Resistance Gene fosA3 among Escherichia coli Isolates from Pigs, Chickens, and Dairy Cows in Northeast China.Antimicrob Agents Chemother2017, 61(9).

3.Song W, Zhang C, Wu J, Qi J,Hua X, Kang L, Yuan Q, Yuan J, Xue Z: Characterization of Three Paris polyphylla Glycosyltransferases from Different UGT Families for Steroid Functionalization.ACS Synth Biol2022, 11(4):1669-1680.

4.Zhang WJ, Wang XM, Dai L,Hua X, Dong Z, Schwarz S, Liu S: Novel conjugative plasmid from Escherichia coli of swine origin that coharbors the multiresistance gene cfr and the extended-spectrum-beta-lactamase gene blaCTX-M-14b.Antimicrob Agents Chemother2015, 59(2):1337-1340.

5.Si H, Zhang WJ, Chu S, Wang XM, Dai L,Hua X, Dong Z, Schwarz S, Liu S: Novel plasmid-borne multidrug resistance gene cluster including lsa(E) from a linezolid-resistant Enterococcus faecium isolate of swine origin.Antimicrob Agents Chemother2015, 59(11):7113-7116.

6.Jiang SG, Zu YG, Zhang L, Fu YJ, Zhang Y, Wang Z,Hua X, Wang JT: Determination of a hydrophilic paclitaxel derivative, 7-xylosyl-10-deacetylpaclitaxel in rat plasma by LC-MS/MS.Biomed Chromatogr2009, 23(5):472-479.

7.Wan D, Jiang C,Hua X, Wang T, Chai Y: Cell cycle arrest and apoptosis induced by aspidin PB through the p53/p21 and mitochondria-dependent pathways in human osteosarcoma cells.Anticancer Drugs2015, 26(9):931-941.

获得专利情况:

1.华欣;刘思国;张万江,新藤黄酸或其衍生物在制备用于预防和/或治疗由细菌引起的相关疾病的药物中的用途,国家发明专利,ZL20170915184.8。

2. 华欣;刘思国;张万江,绵马酚或其衍生物在制备用于预防和/或治疗由细菌引起的相关疾病的药物中的用途,国家发明专利,ZL20170863942.6。

3. 付玉杰;祖元刚;张谡;刘威;孔羽;祖柏实;杨梅;顾成波;华欣,一种从木豆根茎中提取、分离和纯化染料木素的方法,国家发明专利, ZL200910071470.6。

4. 付玉杰;祖元刚;吴楠;孔羽;刘威;华欣,木豆叶中木豆芪酸在制备抗疱疹病毒药物中的应用,国家发明专利, 200910071471。

5. 付玉杰;祖元刚;吴楠;孔羽;刘威;华欣,木豆叶中木豆芪酸及球松素在制备抗疱疹病毒药物中的应用,国家发明专利, CN200910071471.0。

6. 付玉杰;李双明;杨刚;吴楠;罗猛;梁璐;陈晓亮;李政楠;刘霞;吴晓敏;华欣,一种多西紫杉醇新衍生物的合成方法及其在制备抗肿瘤药物中的应用,国家发明专利, CN201010184472.9。

学术兼职

1.国家自然基青年项目通讯评审人(2021-今);

Phytomedicine、Frontiers in Pharmacology等杂志审稿人(2018-今)。

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